Beta Catenin Polyclonal antibody proteintech 17565-1-AP
$449.00
In stock
SKU
17565-1-AP
b cat, B-catenin, beta-Catenin, Catenin beta 1, Catenin beta-1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag11763 Product name: Recombinant human B-catenin protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 433-781 aa of BC058926 Sequence: KNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), IP, CoIP, ELISA | Observed Molecular Weight: 781 aa, 86 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC058926 |
| Conjugate: Unconjugated | Gene Symbol: Beta Catenin |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1499 |
| Application: Western Blot (WB) | RRID: ENSG00000168036 |
| Dilution: WB : 1:2000-1:16000 | Conjugate: AB_2088102 |
| Tested Reactivity: Human, Mouse, Rat | Form: Unconjugated |
| Host / Isotype: Rabbit / IgG | Background Information: β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222) |
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