FBXO6 Monoclonal antibody proteintech 67697-1-Ig
$449.00
In stock
SKU
67697-1-Ig
3B7F9, F box only protein 6, F box protein 6, FBG2, F-box only protein 6
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag30512 Product name: Recombinant human FBXO6 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-293 aa of BC020880 Sequence: MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF Predict reactive species |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 293 aa, 34 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC020880 |
| Conjugate: Unconjugated | Gene Symbol: FBXO6 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 26270 |
| Application: Western Blot (WB) | RRID: AB_2882889 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: FBXO6(F-box only protein 6 ) is also named as FBG2, FBS2, FBX6 and belongs to the F-box protein family. FBXO6 is the substrate recognition component of a Skp1-Cullin1-F-box protein (SCF) ubiquitin E3 ligase complex, recognizing the chitobiose in unfolded N-glycoprotein to target glycoproteins for polyubiquitination and degradation. It can regulate Chk1 ubiquitination and degradation in both normally cycling cells and during replication stress. This protein is mainly detected in the cytoplasm in both cultured cells and in tumor tissues. Its expression is a predictive biomarker of tumor responsiveness to the important anticancer drugs. Positive Fbxo6 expression correlated with early TNM stage and favorable prognosis of NSCLC patients. (PMID:19716789, PMID: 27855403, PMID: 31140586). |
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