Bestrophin-1 Monoclonal antibody proteintech 60326-1-Ig
$449.00
In stock
SKU
60326-1-Ig
ARB, BEST, BEST1, bestrophin 1, Bestrophin-1, BMD, TU15B, VMD2
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag15129 Product name: Recombinant human BEST1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 319-498 aa of BC015220 Sequence: ANSRTKLLWPKRESLLHEGLPKNHKAAKQNVRGQEDNKAWKLKAVDAFKSAPLYQRPGYYSAPQTPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSSGAKKSFELLSESDGALMEHPEVSQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTTLKDHMDPYWALENRDEAHS Predict reactive species |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 585 aa, 68 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC015220 |
| Conjugate: Unconjugated | Gene Symbol: Bestrophin/BEST1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7439 |
| Application: Western Blot (WB) | RRID: AB_2881436 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD). |
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