ACVR1 Monoclonal antibody proteintech 67417-1-Ig
$449.00
In stock
SKU
67417-1-Ig
activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI
| Host / Isotype: Mouse / IgG2a | Class: Monoclonal |
| Reactivity: Human, Pig, Mouse, Rat And More (1) | Immunogen: CatNo: Ag13508 Product name: Recombinant human ACVR1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 210-509 aa of BC033867 Sequence: LLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC Predict reactive species |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 509 aa, 57 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC033867 |
| Conjugate: Unconjugated | Gene Symbol: ACVR1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 90 |
| Application: Western Blot (WB) | RRID: AB_2882657 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Pig, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG2a | Background Information: ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017). |
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