NeutraKine? TNF-alpha Mouse McAb proteintech 69002-1-Ig
$339.00
In stock
SKU
69002-1-Ig
NeutraKine? TNF Alpha, TNF, TNF alpha, TNF-a, 11H8A5
| Host / Isotype: Mouse / IgG1 | Class: Antibody |
| Reactivity: human | Immunogen: tumor necrosis factor (TNF superfamily, member 2) |
| Applications: Neutralization, ELISA | Observed Molecular Weight: 7124 |
| Formulation: Sterile PBS | GenBank Accession Number: AB_2882920 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Gene ID (NCBI): Lyophilized Powder | |
| RRID: Protein G purification | |
| Conjugate: P01375 | |
| Tested Reactivity: Human | Form: Sterile PBS, pH 7.4. |
| Host / Isotype: Monoclonal | Background Information: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer. This antibody can be used to neutralize the bioactivity of TNF alpha. |
Reviews
Write Your Own Review