NeutraKine? IL-17A Mouse McAb proteintech 69021-1-Ig
$339.00
In stock
SKU
69021-1-Ig
IL 17, IL17, IL-17, IL17A, 1F3E3
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human | Immunogen: Recombinant Protein Predict reactive species |
| Applications: Neutralization, ELISA, Cell treatment | Observed Molecular Weight: IL-17A |
| Formulation: Sterile PBS | GenBank Accession Number: ENSG00000112115 |
| Conjugate: Unconjugated | Gene Symbol: AB_2918841 |
| Tested Applications: Neutralization | Gene ID (NCBI): Unconjugated |
| RRID: Lyophilized Powder | |
| Conjugate: Protein G purification | |
| Tested Reactivity: Human | Form: Q16552 |
| Host / Isotype: Mouse / IgG1 | Background Information: IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody can be used to neutralize the bioactivity of IL-17A. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
