Anti-Human MICA/MICB (6D4) proteintech 65161-1-Ig
$220.00
In stock
SKU
65161-1-Ig
MICA, MICB
| Host / Isotype: Mouse / IgG2a, kappa | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: Transfected C1R cells expressing MICA Predict reactive species |
| Applications: WB, FC | Observed Molecular Weight: 383 aa, 43 kDa |
| Formulation: PBS, Azide | GenBank Accession Number: MICA |
| Conjugate: Unconjugated | Gene Symbol: 100507436 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): AB_2881478 |
| Application: Flow Cytometry (FC) | RRID: Unconjugated |
| Dilution: FC : 0.2 ug per 10^6 cells in 100 μl suspension | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Purified by protein-A affinity chromatography |
| Host / Isotype: Mouse / IgG2a, kappa | Background Information: Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). The monoclonal antibody 6D4 recognizes MICA and MICB. |
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