4-Hydroxynonenal Monoclonal antibody proteintech 68538-1-Ig
$449.00
In stock
SKU
68538-1-Ig
Cas. 75899-68-2, C9H16O2, 4-Hydroxy-2-nonenal, 4-HNE
| Host / Isotype: Mouse / IgG2a | Class: Monoclonal |
| Reactivity: 4-Hydroxynonenal, Chemical Compound And More (2) | Immunogen: PTG Predict reactive species |
| Applications: WB, IHC, IF, ELISA | |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: AB_3085246 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive ELISA detected in | Gene ID (NCBI): Liquid |
| Application: Enzyme-linked Immunosorbent Assay (ELISA) | RRID: Protein A purification |
| Dilution: ELISA : 1:5000-1:20000 | Conjugate: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Tested Reactivity: 4-Hydroxynonenal, Chemical Compound | Form: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
| Host / Isotype: Mouse / IgG2a | Background Information: 4-Hydroxynonenal is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. 4-Hydroxynonenal (4-HNE) is a major aldehydic product of ω-6-unsaturated fatty acid peroxidation. It is considered a lipid peroxidation specific marker. 4-HNE has been found to induce differentiation and inhibit proliferation of HL-60 human leukemic cells. It has also been found to induce murine alveolar macrophage cell death. 4-HNE has been shown to inhibit State 3 respiration, causing a transient cytosolic Ca2+ increase. In addition, it irreversibly inhibits Na+-K+-ATPase activity. |
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