SRPX2 Monoclonal antibody proteintech 66266-1-Ig
$449.00
In stock
SKU
66266-1-Ig
BPP, CBPS, PMGX, RESDX, SRPUL, SRPX2
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: human, pig, mouse | Immunogen: CatNo: Ag8084 Product name: Recombinant human SRPX2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 166-465 aa of BC020733 Sequence: DGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGASCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 465 aa, 53 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC020733 |
| Conjugate: Unconjugated | Gene Symbol: SRPX2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 27286 |
| Application: Western Blot (WB) | RRID: AB_2721268 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: human, pig, mouse | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: SRPX2 (sushi-repeat-containing protein, X-linked 2) is a secreted protein expressed in neurons of the human adult brain, including the rolandic area (PMID: 20874700). Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level, SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR, the urokinase-type plasminogen activator (uPA) receptor (PMID: 18718938). It is involved in seizure disorders, angiogenesis and cellular adhesion (PMID: 22242148; 19667118; 16497722). The involvement of SRPX2 in disorders of language cortex suggests it has an important role in the perisylvian region critical for language and cognitive development (PMID: 16497722). |
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