ROCK1 Monoclonal antibody proteintech 66782-1-Ig
$449.00
In stock
SKU
66782-1-Ig
3G5E12, EC:2.7.11.1, p160 ROCK 1, p160 ROCK-1, P160ROCK
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag16317 Product name: Recombinant human ROCK1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 401-710 aa of BC113114 Sequence: SNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKS Predict reactive species |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 1354 aa, 158 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC113114 |
| Conjugate: Unconjugated | Gene Symbol: ROCK1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 6093 |
| Application: Western Blot (WB) | RRID: AB_2882127 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: ROCK1, also named as p160ROCK and NY-REN-35, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. ROCK1 phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. ROCK1 is required for centromere positioning and centromere-dependent exit from mitosis. It is necessary for apoptotic membrane blebbing. ROCK1 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. |
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