SETD1A Monoclonal antibody proteintech 67936-1-Ig
$449.00
In stock
SKU
67936-1-Ig
hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag30424 Product name: Recombinant human SETD1A protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-160 aa of NM_014712 Sequence: MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSV Predict reactive species |
| Applications: WB, IF, ELISA | Observed Molecular Weight: 186 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_014712 |
| Conjugate: Unconjugated | Gene Symbol: SETD1A |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 9739 |
| Application: Western Blot (WB) | RRID: AB_2918688 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: SETD1A is a SET domain-containing methyltransferase involved in the epigenetic regulation of transcription(PMID:12670868). It is the main catalytic component of a multiprotein complex that methylates lysine 4 of histone H3, a histone mark associated with gene activation (PMID:29937342). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PMID:31197650). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). SETD1A has a calculated molecular weight of 186 kDa, and a 258 kDa band was also reported (PMID: 31076518). |
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