NeutraKine? IL-10 Mouse McAb proteintech 69018-1-Ig
$339.00
In stock
SKU
69018-1-Ig
IL-10, IL-10,IL10, 1E4F5, CSIF, IL 10
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Product name: HumanKine? recombinant human IL-10 protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species |
| Applications: IHC, IF, Neutralization, ELISA | Observed Molecular Weight: IL-10 |
| Formulation: Sterile PBS | GenBank Accession Number: AB_2918838 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Gene ID (NCBI): Lyophilized Powder | |
| RRID: Protein G purification | |
| Conjugate: P22301 | |
| Tested Reactivity: Human | Form: Sterile PBS, pH 7.4. |
| Host / Isotype: Mouse / IgG1 | Background Information: Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. This antibody can be used to neutralize the bioactivity of IL-10. |
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