Anti-Mouse CD8a (53-6.7) proteintech 65069-1-Ig
$64.00
In stock
SKU
65069-1-Ig
CD8, 53-6.7, CD8 antigen, alpha chain, CD8α, Ly 2
| Host / Isotype: Rat / IgG2a, kappa | Class: Monoclonal |
| Reactivity: mouse | Immunogen: Spleen cells or thymocyte membranes Predict reactive species |
| Applications: FC | Observed Molecular Weight: BC030679 |
| Formulation: PBS, Azide | GenBank Accession Number: 12525 |
| Conjugate: Unconjugated | Gene Symbol: AB_2881470 |
| Tested Applications: Positive IF-P detected in | Gene ID (NCBI): Unconjugated |
| Application: Immunofluorescence (IF)-P | RRID: Liquid |
| Dilution: IF-P : 1:400-1:1600 | Conjugate: Protein G purification |
| Tested Reactivity: Mouse | Form: P01731 |
| Host / Isotype: Rat / IgG2a, kappa | Background Information: CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer, while CD8αα homodimers alone have been found on some gut intraepithelial T cells, on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). |
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