Anti-Human CD146/MCAM (P1H12) proteintech 65181-1-Ig
$75.00
In stock
SKU
65181-1-Ig
CD146, MCAM, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MUC18
| Host / Isotype: Mouse / IgG1, kappa | Class: Monoclonal |
| Reactivity: human, mouse, rabbit, canine | Immunogen: cultured human umbilical cells Predict reactive species |
| Applications: WB, IF/ICC, FC | Observed Molecular Weight: 646 aa, 72 kDa |
| Formulation: PBS, Azide | GenBank Accession Number: CD146 |
| Conjugate: Unconjugated | Gene Symbol: 4162 |
| Tested Applications: Positive IF/ICC detected in | Gene ID (NCBI): AB_2881483 |
| Application: Immunofluorescence (IF)/ICC | RRID: Unconjugated |
| Dilution: IF/ICC : 1:500-1:2000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rabbit, Canine | Form: Purified by protein-A affinity chromatography |
| Host / Isotype: Mouse / IgG1, kappa | Background Information: CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein of 113-130 kDa, belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324; 25993332). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677). In addition to the membrane-anchored form of CD146, a soluble form of CD146 (sCD146, 105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells (PMID: 9462829; 19229070; 16374253; 14597988). |
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