KLRB1/CD161 Monoclonal antibody proteintech 67537-1-Ig
$449.00
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SKU
67537-1-Ig
CD161, 3D8F5, CLEC5B, C-type lectin domain family 5 member B, hNKR P1A
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human | Immunogen: CatNo: Ag27117 Product name: Recombinant human KLRB1,CD161 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 68-225 aa of BC114516 Sequence: KSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 225 aa, 25 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC114516 |
| Conjugate: Unconjugated | Gene Symbol: CD161 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3820 |
| Application: Western Blot (WB) | RRID: ENSG00000111796 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: AB_2882756 |
| Tested Reactivity: Human | Form: Unconjugated |
| Host / Isotype: Mouse / IgG1 | Background Information: CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665). |
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