SYK Monoclonal antibody proteintech 66721-1-Ig
$449.00
In stock
SKU
66721-1-Ig
4C4A12, EC:2.7.10.2, IMD82, p72-Syk, spleen tyrosine kinase
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Human And More (2) | Immunogen: CatNo: Ag17654 Product name: Recombinant human SYK protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 239-427 aa of BC001645 Sequence: QLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL Predict reactive species |
| Applications: WB, IHC, IF-P, IP, ELISA | Observed Molecular Weight: 635 aa, 72 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC001645 |
| Conjugate: Unconjugated | Gene Symbol: SYK |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 6850 |
| Application: Western Blot (WB) | RRID: ENSG00000165025 |
| Dilution: WB : 1:2000-1:10000 | Conjugate: AB_2882072 |
| Tested Reactivity: Human | Form: Unconjugated |
| Host / Isotype: Mouse / IgG2b | Background Information: SYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. Although SYK has not been linked to a human disease, defective expression of the closely related T-cell tyrosine kinase ZAP-70 has been associated with severe combined immunodeficiency(PMID:11494125). This protein has 2 isoforms produced by alternative splicing. SYK also promotes liver fibrosis by activation of hepatic stellate cells and acts as a biomarker for human hepatocellular carcinoma. (PMID: 29537660) |
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