LGMN Monoclonal antibody proteintech 67017-1-Ig
$449.00
In stock
SKU
67017-1-Ig
AEP, Asparaginyl endopeptidase, legumain, LGMN, LGMN1, Protease, cysteine 1, PRSC1
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Pig, Mouse And More (1) | Immunogen: CatNo: Ag7218 Product name: Recombinant human LGMN protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 82-433 aa of BC003061 Sequence: TPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY Predict reactive species |
| Applications: WB, IHC, IF-P, ELISA | Observed Molecular Weight: 49 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC003061 |
| Conjugate: Unconjugated | Gene Symbol: LGMN |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5641 |
| Application: Western Blot (WB) | RRID: AB_2882333 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Pig, Mouse | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: LGMN (Legumain), also known as asparaginyl endopeptidase or AEP, is a broadly expressed lysosomal cysteine endopeptidase that belongs to peptidase family C13 and specifcally hydrolyzes substrate asparaginyl bonds (PMID: 9065484). LGMN directly regulates diverse physiological and pathological processes by remodeling tissue-specific targets (PMID: 25205715, 21292981, 18820679). In addition, LGMN indirectly contributes to atherosclerotic plaque instability through activation of cathepsin L in the arterial ECM (PMID: 19671471, 18377911). LGMN is secreted as inactive prolegumain (56 kDa) and processed into enzymatically active 46 and 36 kDa forms, as well as a 17 kDa enzymatically inactive C-terminal fragment (PMID: 28162997, PMID: 19671471). |
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