Follistatin Monoclonal antibody proteintech 60060-1-Ig
$449.00
In stock
SKU
60060-1-Ig
FST, FS, Activin-binding protein, Activin binding protein, 4E9B10
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Human And More (3) | Immunogen: CatNo: Ag0775 Product name: Recombinant human FST protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-344 aa of BC004107 Sequence: MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 33 aa, 7 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC004107 |
| Conjugate: Unconjugated | Gene Symbol: Follistatin |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 10468 |
| Application: Western Blot (WB) | RRID: AB_2106706 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor11 , and myostatin. It binds activin A with high affinity and whose expression can be induced by activin A and several other pro-inflammatory cytokines. Activin A-follistatin complexes are biologically inactive and bind to cell surface heparan sulphate-containing proteoglycans for internalisation and degradation. It has also been found to play a significant role in the management of skeletal muscle size and mass. It also has important roles in early embryonic development, differentiation of ovarian granulosa cells, liver fibrosis and polycystic ovarian syndrome. FS 288 glycosylation results in a major species of 35 kDa and a less abundant 40 kDa and minor products of 40 and 42 kDa (PMID: 9785474). Three typical follistatin bands are at 32, 35, and 39 kDa (PMID: 2036994). |
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