Phospho-TDP43 (Ser403/404) Monoclonal antibody proteintech 66079-1-Ig
$449.00
In stock
SKU
66079-1-Ig
ALS10, Phospho-TDP43 (Ser403/404), TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43
| Host / Isotype: Mouse / IgG2a | Class: Monoclonal |
| Reactivity: human, mouse and More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 43 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_007375 |
| Conjugate: Unconjugated | Gene Symbol: TDP-43 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 23435 |
| Application: Western Blot (WB) | RRID: AB_11183767 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: human, mouse | Form: Liquid |
| Host / Isotype: Mouse / IgG2a | Background Information: Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). Various forms of TDP-43 exist, including 18-35 kDa of cleaved C-terminal fragments, 45-50 kDa phospho-protein, 55 kDa glycosylated form, 75 kDa hyperphosphorylated form, and 90-300 kDa cross-linked form. (PMID: 17023659,19823856, 21666678, 22193176).66079-1-Ig is a mouse monoclonal antibody recognizing TDP-43 only when phosphorylated at 403/404. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining. |
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