ACLY Monoclonal antibody proteintech 67166-1-Ig
$449.00
In stock
SKU
67166-1-Ig
ATP citrate lyase, 1E10D5, ACL, ATP-citrate, ATP-citrate synthase
| Host / Isotype: Mouse / IgM | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag7709 Product name: Recombinant human ACLY protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 751-1101 aa of BC006195 Sequence: MFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, ELISA | Observed Molecular Weight: 121 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC006195 |
| Conjugate: Unconjugated | Gene Symbol: ACLY |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 47 |
| Application: Western Blot (WB) | RRID: AB_2882462 |
| Dilution: WB : 1:1000-1:10000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgM | Background Information: ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma, ACLY is overexpressed compared with normal parenchyma suggesting that ACLY may represent a common target among highly malignant tumors(PMID:19795461). This protein has 2 isoforms produced by alternative splicing. |
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