UBE2C Monoclonal antibody proteintech 66087-1-Ig
$449.00
In stock
SKU
66087-1-Ig
(E3-independent) E2 ubiquitin-conjugating enzyme C, 1C12H8, E2 ubiquitin-conjugating enzyme C, EC:2.3.2.23, EC:2.3.2.24
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag19235 Product name: Recombinant human UBE2C protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-179 aa of BC016292 Sequence: MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP Predict reactive species |
| Applications: WB, IHC, IF/ICC, CoIP, ELISA | Observed Molecular Weight: 179 aa, 20 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC016292 |
| Conjugate: Unconjugated | Gene Symbol: UBE2C |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 11065 |
| Application: Western Blot (WB) | RRID: AB_11232220 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: UBE2C(Ubiquitin-conjugating enzyme E2 C) is also known as UBCH10 and belongs to the ubiquitin-conjugating enzyme family. It is highly expressed in a variety of human primary tumors, and it is able to promote cell proliferation and malignant transformation(PMID:18703417). UBE2C, along with the E3 ligase of the anaphasepromoting complex (APC), catalyzes the ubiquitination of mitotic cyclins A and B, as well as securin. UBE2C is essential for cell cycle progression, and mutation of its active site cysteine confers a dominant-negative phenotype(PMID:17217624). |
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