p21 Monoclonal antibody proteintech 67362-1-Ig
$449.00
In stock
SKU
67362-1-Ig
Cdkn1a, p21WAF, p21Cip1, P21 protein, Cdkn1
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Mouse And More (2) | Immunogen: CatNo: Ag28394 Product name: Recombinant mouse Cdkn1a protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-159 aa of NM_001111099 Sequence: MSNPGDVRPVPHRSKVCRCLFGPVDSEQLRRDCDALMAGCLQEARERWNFDFVTETPLEGNFVWERVRSLGLPKVYLSPGSRSRDDLGGDKRPSTSSALLQGPAPEDHVALSLSCTLVSERPEDSPGGPGTSQGRKRRQTSLTDFYHSKRRLVFCKRKP Predict reactive species |
| Applications: IF/ICC, ELISA | Observed Molecular Weight: 18 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: p21 |
| Conjugate: Unconjugated | Gene Symbol: 12575 |
| Tested Applications: Positive IF/ICC detected in | Gene ID (NCBI): AB_2882614 |
| Application: Immunofluorescence (IF)/ICC | RRID: Unconjugated |
| Dilution: IF/ICC : 1:50-1:500 | Conjugate: Liquid |
| Tested Reactivity: Mouse | Form: Protein A purification |
| Host / Isotype: Mouse / IgG2b | Background Information: CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. |
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