CRM1 Monoclonal antibody proteintech 66763-1-Ig
$449.00
In stock
SKU
66763-1-Ig
XPO1, 2D3B6, Exp1, Exportin 1, Exportin-1
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag27337 Product name: Recombinant human XPO1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 301-540 aa of BC032847 Sequence: NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII Predict reactive species |
| Applications: WB, IHC, IF, IP, ELISA | Observed Molecular Weight: 1071 aa, 123 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC032847 |
| Conjugate: Unconjugated | Gene Symbol: CRM1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7514 |
| Application: Western Blot (WB) | RRID: AB_2882109 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ). |
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