Sestrin 2 Monoclonal antibody proteintech 66297-1-Ig
$449.00
In stock
SKU
66297-1-Ig
HI95, SES2, SESN2, SEST2, sestrin 2, Sestrin2
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, pig, rat and More (2) | Immunogen: CatNo: Ag20638 Product name: Recombinant human Sestrin2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 132-480 aa of BC013304 Sequence: HMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, CoIP, ELISA | Observed Molecular Weight: 54 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC013304 |
| Conjugate: Unconjugated | Gene Symbol: SESN2/Sestrin 2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 83667 |
| Application: Western Blot (WB) | RRID: AB_2881680 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: human, pig, rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 2 is implicated in the regulation of cell survival, in cellular responses to different stress conditions, and also acts as a positive regulator of autophagy. Sestrin 2 is approximately a 57.6kDa protein (480 amino acids). |
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