BNIP3 Monoclonal antibody proteintech 68091-1-Ig
$449.00
In stock
SKU
68091-1-Ig
2H7D8, NIP3
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag27935 Product name: Recombinant human BNIP3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-194 aa of BC009342 Sequence: MQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF Predict reactive species |
| Applications: WB, IHC, IF/ICC, CoIP, ELISA | Observed Molecular Weight: 194 aa, 22 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC009342 |
| Conjugate: Unconjugated | Gene Symbol: BNIP3 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 664 |
| Application: Western Blot (WB) | RRID: AB_2918828 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: BNIP3 (BCL2 interacting protein 3) is a member of the Bcl-2 family that is expressed in mitochondria and induces apoptosis (PMID: 10891486). It can regulate the permeabillity state of outer mitchondrial member (OMM), this regulation is accompanied by the formation of homo- and hetero-oligomers inside the membrane. Hypoxia can lead to transcriptional activation of BNIP3 through HIF-1α (PMID: 11559532). It's calculated molecule weight is 21.5?kDa. The antibody can detect bands around 25 and 50?kDa, representing monomeric and dimeric forms, respectively (PMID: 21364626).BNIP3 is related to the occurrence and development of tumors, cardiovascular diseases, and Parkinson's diseases. |
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