IkB Alpha Monoclonal antibody proteintech 66418-1-Ig
$449.00
In stock
SKU
66418-1-Ig
IKBA, IκB α, NFKBIA, 2G6H7, I kappa B alpha
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag22040 Product name: Recombinant human NFKBIA protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 20-217 aa of BC004983 Sequence: LKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNG Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 36 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC004983 |
| Conjugate: Unconjugated | Gene Symbol: IkB Alpha |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4792 |
| Application: Western Blot (WB) | RRID: AB_2881790 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, synonyms: IKBA, MAD-3, NFKBI). NFKB1 or NFKB2 is bound to REL, RELA , or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
