PMS2 Monoclonal antibody proteintech 68905-5-Ig
$449.00
In stock
SKU
68905-5-Ig
1D1A3, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human, rabbit | Immunogen: PMS2 postmeiotic segregation increased 2 (S. cerevisiae) |
| Applications: WB, IHC, IP, ELISA | Observed Molecular Weight: 117 kDa, 100 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: PMS2 |
| Conjugate: Unconjugated | Gene Symbol: 5395 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Rabbit | Form: P54278 |
| Host / Isotype: Monoclonal | Background Information: PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS). |
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