PHD2/EGLN1 Monoclonal antibody proteintech 66589-1-Ig
$449.00
In stock
SKU
66589-1-Ig
EGLN1, PHD2, EGLN 1, ECYT3, EC:1.14.11.29
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat, pig | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 46 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_022051 |
| Conjugate: Unconjugated | Gene Symbol: PHD2/EGLN1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 54583 |
| Application: Western Blot (WB) | RRID: AB_2881949 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat, Pig | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: EGLN1, also named as PHD2, SM-20, HPH-2 and HIF-PH2, catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. EGLN1 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Defects in EGLN1 are the cause of erythrocytosis familial type 3 (ECYT3). EGLN1 has 3 isoforms with MW of 46 kDa, 44 kDa and 36 kDa produced by alternative splicing. It mainly localizes in cytoplasm and can shuttle between the nucleus and cytoplasm (PubMed:19631610). The antibody is specific to EGLN1. |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
