Phospho-p38 MAPK (Thr180/Tyr182) Polyclonal antibody proteintech 28796-1-AP
$449.00
In stock
SKU
28796-1-AP
p p38 MAPK, p p38 MAPK (Thr180/Tyr182), p38 alpha/MAPK14 (Thr180/Tyr182), p38 MAPK (Thr180/Tyr182), Phospho p38 MAPK
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (3) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 360 aa, 41 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC031574 |
| Conjugate: Unconjugated | Gene Symbol: p38 MAPK |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1432 |
| Application: Western Blot (WB) | RRID: AB_2918205 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and certain mitogens, trigger a stress-regulated protein kinase cascade culminating in activation of p38 MAPK through phosphorylation on a TGY motif within the kinase activation loop. The p38 MAPK undergoes dual phosphorylation at Thr182 and Tyr180 in the Thr-Gly-Tyr activation loop by MAP kinase kinase 6 (MKK6). Upon activation, p38 MAPK phosphorylates multiple substrates, including MAPK activated protein kinase 2 (MAPKAPK2) and activating transcription factor 2 (ATF-2). (PMID:?26901653, PMID:?10807318) |
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