AGO2 Monoclonal antibody proteintech 67934-1-Ig
$449.00
In stock
SKU
67934-1-Ig
EIF2C2, 1G2H12, Ago 2, Argonaute 2, Argonaute RISC catalytic component 2
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag27772 Product name: Recombinant human AGO2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 603-780 aa of BC007633 Sequence: AGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), IP, RIP, ELISA | Observed Molecular Weight: 97 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC007633 |
| Conjugate: Unconjugated | Gene Symbol: EIF2C2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 27161 |
| Application: Western Blot (WB) | RRID: AB_2918686 |
| Dilution: WB : 1:1000-1:5000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: EIF2C2, also named as AGO2, belongs to the argonaute family and Ago subfamily. It is required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). EIF2C2 may inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. It also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. EIF2C2 can also upregulate the translation of specific mRNAs under certain growth conditions. |
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