OTUB1 Monoclonal antibody proteintech 68489-1-Ig
$449.00
In stock
SKU
68489-1-Ig
OTU domain-containing ubiquitin aldehyde-binding protein 1, OTB1, HSPC263, hOTU1, EC:3.4.19.12
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: OTU domain, ubiquitin aldehyde binding 1 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 31-35 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: OTUB1 |
| Conjugate: Unconjugated | Gene Symbol: 55611 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3085200 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Protein A purification |
| Host / Isotype: Monoclonal | Background Information: OTUB1 belongs to the ovarian tumor domain protease (OTU) subfamily of deubiquitinases, which could block ubiquitination leading to protein stability. OTUB1 mainly prefers k-48 and k-63 ubiquitin chains type, especially in k-48 ubiquitin chain. OTUB1 performs its deubiquitinating function via two distinct manners: the canonical and non-canonical manner. OTUB1 is involved in many critical immune response processes, containing CD8 T cell activation, PD-L1 related immune evasion, and several infectious diseases. OTUB1 plays an important role in the occurrence, proliferation, invasion, and progression of various cancers, such as bladder cancer, breast cancer, prostate cancer, and colorectal cancer (PMID: 34875341, 35296795). OTUB1 has 2 isoforms with molecular weights of 31 and 35 kDa, respectively. |
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