Beta Catenin Monoclonal antibody proteintech 66379-1-Ig
$449.00
In stock
SKU
66379-1-Ig
1B8A1, b cat, B-catenin, beta-Catenin, Catenin beta 1
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Mouse, Rat, Pig And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, IF-P, FC (Intra), IP, CoIP, ELISA | Observed Molecular Weight: 781 aa, 86 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_001904 |
| Conjugate: Unconjugated | Gene Symbol: Beta Catenin |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1499 |
| Application: Western Blot (WB) | RRID: ENSG00000168036 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: AB_2857358 |
| Tested Reactivity: Human, Mouse, Rat, Pig | Form: Unconjugated |
| Host / Isotype: Mouse / IgG1 | Background Information: β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222) |
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