CXCR4 Monoclonal antibody proteintech 60042-1-Ig
$449.00
In stock
SKU
60042-1-Ig
CD184, C-X-C chemokine receptor type 4, CXC R4, CXCR 4, CXC-R4
| Host / Isotype: Mouse / IgM | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag1528 Product name: Recombinant human CXCR4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 192-352 aa of BC020968 Sequence: NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS Predict reactive species |
| Applications: WB, IHC, IF, CoIP, ELISA | Observed Molecular Weight: 352 aa, 40 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC020968 |
| Conjugate: Unconjugated | Gene Symbol: CXCR4 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7852 |
| Application: Western Blot (WB) | RRID: AB_2091809 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgM | Background Information: C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some research, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649). |
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