DICER1 Polyclonal antibody proteintech 20567-1-AP
$449.00
In stock
SKU
20567-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: human | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, IF-P, FC (Intra), IP, ELISA | Observed Molecular Weight: 219 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_030621 |
| Conjugate: Unconjugated | Gene Symbol: DICER1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 23405 |
| Application: Western Blot (WB) | RRID: AB_10694287 |
| Dilution: WB : 1:200-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: DICER1, also named as DICER, HERNA and KIAA0928, belongs to the helicase family and Dicer subfamily. It is required for formation of the RNA induced silencing complex (RISC). DICER1 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. DICER1 cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. The antibody is specific to DICER1. The calcualted molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 exists some isoforms with molecular weight 219 kDa and 93 kDa. |
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