LIG4 Polyclonal antibody proteintech 12695-1-AP
$449.00
In stock
SKU
12695-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag3385 Product name: Recombinant human LIG4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 606-911 aa of BC037491 Sequence: ASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 911 aa, 104 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC037491 |
| Conjugate: Unconjugated | Gene Symbol: LIG4 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3981 |
| Application: Western Blot (WB) | RRID: AB_2136253 |
| Dilution: WB : 1:500-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: human, mouse, rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand brdownloadeaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4. |
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