Phospho-YAP1 (Ser397) Polyclonal antibody proteintech 29018-1-AP
$449.00
In stock
SKU
29018-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 504 aa, 54 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC038235 |
| Conjugate: Unconjugated | Gene Symbol: YAP1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 10413 |
| Application: Western Blot (WB) | RRID: AB_2923587 |
| Dilution: WB : 1:2000-1:16000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: The transcriptional factors Yes-associated protein 1 (YAP1) and PDZ-binding motif (TAZ) act as downstream effectors of the Hippo pathway, and their subcellular location and transcriptional activities are affected by multiple post-translational modifications (PTMs). After phosphorylation, YAP1/TAZ binds to the 14-3-3 protein, which induces cytoplasmic retention of YAP1/TAZ. Moreover, phosphorylated YAP1/TAZ is likely to undergo ubiquitination degradation that is dependent on the β-transducin repeat-containing E3 ubiquitin protein ligase complex. The phosphorylation of YAP at Ser127 promotes its cytoplasmic retention, whereas phosphorylation at Ser397 induces degradation. (PMID:?29682330, PMID:?26039999) |
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