Osteopontin Polyclonal antibody proteintech 22952-1-AP
$449.00
In stock
SKU
22952-1-AP
OPN, BNSP, Bone sialoprotein 1, BSPI, ETA 1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (3) | Immunogen: CatNo: Ag19216 Product name: Recombinant human OPN, SPP1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 13-300 aa of BC007016 Sequence: ITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQTLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), CoIP, ELISA | Observed Molecular Weight: 314 aa, 35 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC007016 |
| Conjugate: Unconjugated | Gene Symbol: Osteopontin |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 6696 |
| Application: Western Blot (WB) | RRID: AB_2783651 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Osteopontin (OPN), also known as SPP1, is a secreted glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. Originally isolated from bone, OPN has been found in kidneys, vascular tissues, biological fluids, and various tumor tissues (PMID: 15138464; 16406521). OPN can interact with CD44 and integrins and regulate diverse biological processes. It has a multifaceted role in bone development and remodeling, and is also involved in the inflammatory and immune response, oncogenesis and cancer progression. The very acidic nature of OPN, as well as the presence of variable posttranslational modifications, has led to anomalous migration in SDS-polyacrylamide gels and therefore to reports of different molecular weights for OPN (PMID: 8293561). Depending on the cell and tissue source and/or the SDS-PAGE system, OPN migrates with a molecular weight of 44-80 kDa, as well as at some smaller bands corresponding to peptide fragments (PMID: 8195113; 17890765). |
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