PKM Polyclonal antibody proteintech 10078-2-AP
$449.00
In stock
SKU
10078-2-AP
PKM1, PK-M1, PKM1 pyruvate kinase, muscle, PKM2, PK-M2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag0110 Product name: Recombinant human PKM protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 11-221 aa of BC000481 Sequence: AFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAV Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), IP, ELISA | Observed Molecular Weight: 58 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000481 |
| Conjugate: Unconjugated | Gene Symbol: PKM |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5315 |
| Application: Western Blot (WB) | RRID: AB_2283775 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PKM, also named as OIP3, PK2, PK3, PKM1/2, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. PKM has 2 isoforms named as PKM1/M2. The activity of the M2 isoform can be inhibited by tyrosine kinase signalling in tumourcells. The primary pyruvate kinase isoform before tumour development is PKM1; however, the primary isoform from four independent tumours is PKM2.(PMID:18337823). This antibody can recognize both PKM1 and PKM2. |
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