Phospho-PERK/EIF2AK3 (Ser719) Polyclonal antibody proteintech 29546-1-AP
$449.00
In stock
SKU
29546-1-AP
p PERK/EIF2AK3, p PERK/EIF2AK3 (Ser719), p PERK/EIF2AK3 Ser719, PERK/EIF2AK3 (Ser719), Phospho PERK/EIF2AK3
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, IP, ELISA | Observed Molecular Weight: 1116 aa, 125 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC126354 |
| Conjugate: Unconjugated | Gene Symbol: PERK |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 9451 |
| Application: Western Blot (WB) | RRID: AB_2935416 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: EIF2AK3 encodes the protein kinase RNA-like ER kinase (PERK), a key regulator of the unfolded protein response (UPR) in response to ER stress. Under ER stress conditions, activation of PERK is triggered by the dissociation of glucose-regulated protein (GRP) 78 (also known as BiP) from its luminal domain, followed by oligomerization and autophosphorylation. Phosphorylated PERK subsequently phosphorylates eukaryotic translation initiation factor 2 alpha (eif2α), to attenuate global protein translation and reduce incoming ER protein load via upregulated ER chaperone expression. (PMID: 35922637, PMID: 32029570) |
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