RAB8A Polyclonal antibody proteintech 55296-1-AP
$449.00
In stock
SKU
55296-1-AP
MEL, Oncogene c mel, RAB8, RAB8A, Ras related protein Rab 8A
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, RIP, ELISA | Observed Molecular Weight: 24 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_005370 |
| Conjugate: Unconjugated | Gene Symbol: RAB8A |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4218 |
| Application: Western Blot (WB) | RRID: AB_10858398 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring. RAB8 has two isoforms, RAB8A and RAB8B, that share 40% amino acid identity in the C-terminal variable region. RAB8 activity is regulated by specific guanine nucleotide exchange factors (GEFs), that mediate GTP loading, and GTPase activating proteins (GAPs) that convert them into the inactive GDP-bound form. RAB8 participates in recycling of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to the dendritic spine surface as well as in the intracellular transport of the metabotropic glutamate receptor type 1 in neuronal cells. Rab8 is activated at the base of the cilium by its guanine nucleotide exchanger Rabin8. The antibody 11792-1-AP can detect both RAB8A and RAB8B. 55295-1-AP is specific to RAB8B and 55296-1-AP is specific to RAB8A. |
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