Cyclin D1 Polyclonal antibody proteintech 26939-1-AP
$449.00
In stock
SKU
26939-1-AP
CCND1, B cell lymphoma 1 protein, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (5) | Immunogen: CatNo: Ag25393 Product name: Recombinant human Cyclin D1 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 193-295 aa of BC000076 Sequence: VKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), ELISA | Observed Molecular Weight: 295 aa, 34 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000076 |
| Conjugate: Unconjugated | Gene Symbol: Cyclin D1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 595 |
| Application: Western Blot (WB) | RRID: AB_2880691 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: CCND1 (cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis. Cyclin D1 may have a molecular weight of 45kDa due to SUMO modification. |
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