Anti-Human CD146/MCAM (P1H12) Proteintech 65181-1-Ig
$299.00
In stock
SKU
65181-1-Ig
CD146, MCAM, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MUC18
| Formulation:：PBS, Azide | Formulation:：PBS, Azide1 |
| Applications：Immunofluorescence (IF)/ICC | Formulation:：PBS, Azide2 |
| Reactivity：Human | Formulation:：PBS, Azide3 |
| Type：Antibody | Formulation:：PBS, Azide4 |
| RRID：CD146 | Formulation:：PBS, Azide5 |
| Storage Buffer：Liquid | Formulation:：PBS, Azide6 |
| Background Information：CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein of 113-130 kDa, belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324; 25993332). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677). In addition to the membrane-anchored form of CD146, a soluble form of CD146 (sCD146, 105 kDa) has also been found in human plasma and in the supernatant of cultured human endothelial cells (PMID: 9462829; 19229070; 16374253; 14597988). | Formulation:：PBS, Azide7 |
| biogegep8 | Formulation:：PBS, Azide8 |
| biogegep9 | Formulation:：PBS, Azide9 |
| Formulation:：PBS, Azide0 | Applications：Immunofluorescence (IF)/ICC0 |
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