Anti-Mouse PD-1/CD279 (RMP1-14) Rat IgG2a Recombinant Antibody Proteintech 65684-1-TR
$299.00
In stock
SKU
65684-1-TR
CD279, PD1, PD-1, PD 1, Pdc1
| Formulation:：PBS, Azide | Formulation:：PBS, Azide1 |
| Applications：FUNCTIONAL ASSAY | Formulation:：PBS, Azide2 |
| Reactivity：Rat / IgG2a | Formulation:：PBS, Azide3 |
| Type：Mouse PD-1 transfected BHK cells Predict reactive species | Formulation:：PBS, Azide4 |
| RRID：Unconjugated | Formulation:：PBS, Azide5 |
| Storage Buffer：Store at 2-8°C. Stable for one year after shipment. | Formulation:：PBS, Azide6 |
| Background Information：Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein and can be used in mouse models to block the reaction between PD-1 and PD-L1/PD-L2 (PMID: 14764726; 31832706). | Formulation:：PBS, Azide7 |
| biogegep8 | Formulation:：PBS, Azide8 |
| biogegep9 | Formulation:：PBS, Azide9 |
| Formulation:：PBS, Azide0 | Applications：FUNCTIONAL ASSAY0 |
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