Adenovirus Packaging
Recombinant adenovirus (AdV) is a widely used replication-defective adenoviral vector system in gene therapy, basic life science research, and other fields. The commonly used adenoviral vectors are based on human adenovirus type 5 (Ad5), which has a linear double-stranded DNA genome of 36 kb. Adenoviruses can enter cells by binding their fibers to cell surface receptors, followed by internalization into endosomes and subsequent transfer to the cytoplasm and nucleus. With the assistance of cellular transcription and translation machinery, viral replication and assembly are initiated. A complete viral life cycle leads to cell death, resulting in the release of viral particles.
Adenoviruses have the following characteristics
Wide range of infection
Adenovirus can be used to infect ordinary cell lines, suspended cells, primary cells and so on
High infection efficiency
The titer of adenovirus can be as high as 1011PFU/ml, and the infection efficiency is high, which can infect suspension cells and primary cells.
Large carrier capacity
The vector capacity of adenovirus is large, up to 8kb.
provides adenovirus-related services
1. Conventional gene overexpression/interfering Adenovirus pacakging
2.MiRNAsponge/antago adenovirus
3.CircRNA /LncRNA overexpression and interference adenovirus
4.CRISPR/Cas9 denovirus customization
5.Adenovirus purification services
6.Adenovirus stock products
provides products
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